In the prior era of this championship, it was used to transition a mini (Damiancito el Guerrero, who soon became Virus) into his new role as a full sized wrestler. Virus lost the belt to Ricky Marvin, in similar bid to give more spotlight to a small wrestler. Marvin lost in turn to Loco Max, who was a local Arena Puebla wrestler at the time. If there were further plans for the championship, they were forgotten after Loco Max joined the main CMLL roster (thru the Guapos U group) in 2002. Luchas 2000's special on the history of the Mexican National Championships included an interview with Loco Max, who said he vacated this championship, but no specific date was mentioned.
As usual, CMLL brought this championship back with no notice or advance warning in 2008, announcing a lineup for a tournament to decide a new champion without previously mentioning the title would be returning. It never seemed to be officially announced as such, but the championship has clearly been repurposed as a minis championship, secondary to the CMLL World Minis Championship. All wrestlers in the tournament to decide a new champion were minis, and no normal size wrestler has challenged for it. (No minis wrestler has either, due to the lack of defenses.) It's not said why the Mexican National Minis Championship, a title which exists for this very use, is not being used by CMLL, but the assumption is they don't actually have control of the title.
The lightweight division has rarely had the prominence of the other weight divisions and is usually skipped by most promotions. Perhaps because of this championship switching over to the minis division, CMLL has brought back the CMLL World Super Lightweight Championship to fill this niche.
↑Lucha Libre 31, page 4 - this narrative does not include many dates, but indicates Shadow defended against Juventino Romero sometime before vacating and implies it was prior to 1951
↑Lucha Libre 50 confirms this was a tournament final, say it was actually in June. March 30 wsa previously known date. Orquidea was previously listed as final opponent.